Annemieke Madder 6th Modern Solid Phase Peptide Synthesis & Its Applications Symposium 2017

Annemieke Madder

Annemieke Madder is heading the Organic and Biomimetic Chemistry Research (OBCR) Group. More specifically, major research interests include: – The construction of conformationally defined peptide architectures which find applications as peptide vaccines, peptide hydrogels, protein mimetics, DNA-binding ligands and artificial receptors or synthetic antibodies. – The development of new methods for crosslinking and labeling of biomacromolecules such as peptides, proteins and oligonucleotides, including the versatile furan-oxidation based ligation methodology. – The design of novel reactive peptide and oligonucleotide based probes, including peptide nucleic acids, for applications in antisense and antigene strategies, protein and miRNA/lncRNA target identification and receptor pulldown. Building expertise in peptide and oligonucleotide sciences for more than 20 years, we now try to contribute to tackling the major challenge of targeted delivery of next-generation therapeutic biologicals where successful conjugation chemistries are prerequisite for the success of such therapeutic strategies. In parallel, we exploit the developed technologies for applications in advanced biomarker detection making use of tools such as singlet oxygen (or ROS species on cellular level) and red light activation of photosensitizers to achieve selective precision ligations between and/or to biomolecules.